Enhanced protein fold recognition using secondary structure information from nmr
نویسندگان
چکیده
منابع مشابه
Enhanced protein fold recognition using secondary structure information from NMR.
NMR offers the possibility of accurate secondary structure for proteins that would be too large for structure determination. In the absence of an X-ray crystal structure, this information should be useful as an adjunct to protein fold recognition methods based on low resolution force fields. The value of this information has been tested by adding varying amounts of artificial secondary structur...
متن کاملProtein fold recognition from secondary structure assignments
A method for finding protein folds consistent with secondary structure assignments and imposed experimental restraints is described. All possible matches between the query pattern and every member of a database of protein structural domains are generated by a comparison of secondary structure assignments. The comparison allows for errors in predicted secondary structure elements and possible va...
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We present an analysis of the blind predictions submitted to the fold recognition category for the second meeting on the Critical Assessment of techniques for protein Structure Prediction. Our method achieves fold recognition from predicted secondary structure sequences using hidden Markov models (HMMs) of protein folds. HMMs are trained only with experimentally derived secondary structure sequ...
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متن کاملProtein fold recognition by mapping predicted secondary structures.
A strategy is presented for protein fold recognition from secondary structure assignments (alpha-helix and beta-strand). The method can detect similarities between protein folds in the absence of sequence similarity. Secondary structure mapping first identifies all possible matches (maps) between a query string of secondary structures and the secondary structures of protein domains of known thr...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1999
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.8.5.1127